HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 24772748, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 11956564 | HCID 11956564 | — |
| Product | HCID 24772748 | HCID 24772748 | — |
Reaction Steps
A solution of Example 43 (0.090 g, 0.150 mmol) in DMF was treated with o-Benzylhyroxylamine hydrochloride (27 mg, 0.165 mmol), HBTU (0.063 g, 0.165 mmol), and DIEA (0.150 mL, 0.829 mmol) by the general procedure A. The crude product was purified by flash chromatography (silica, Hexanes:EtOAc) to afford 74 mg of title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208601B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-678bff5f008f41b0b3f2fa6dddec1d0c |
| Source note | uspto-grants-2007_04 |