Sodium Bicarbonate → HCID 10301643, compound

Participants

Reaction Conditions

Reaction Steps

3-Bromo-N-[3-t-butyl-1-(4-methylphenyl)-pyrazol-5-yl]-4-methylbenzamide (Intermediate 2 2, 43 mg), N-cyclopropylmethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide (33 mg), tetrakis(triphenylphosphine)palladium (2 mg) and aqueous sodiumhydrogen carbonate (1M, 0;5 ml) were mixed in propan-2-ol (2 ml) and heated at 85° C. under nitrogen for 96 hrs. The cooled reaction was absorbed onto silica and applied to a SPE cartridge (Si, 5 g) and eluted with an ethyl acetate/cylohexane gradient (0–100% ethyl acetate). The product fractions were reduced to dryness under vacuum to give N3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N4′-(cyclopropylmethyl)-6-methyl-1,1′-biphenyl-3,4′-dicarboxamide.

Provenance & Evidence