反应详情

温度

40 °C

Morpholine (200 μl) was added to a solution of 2-amino-5-chloro-1,3,4-thiadiazole (60 mg) in ethanol (2 ml) and the mixture heated in a sealed vial at 40° C. for 6 hours. The ethanol was evaporated from the cooled reaction under vacuum, the residue diluted with water and filtered. The filtrate was extracted with ethyl acetate (x2), the extracts dried (MgSO4) and the solvent removed under vacuum to give 2-amino-5-morpholinyl-1,3,4-thiadiazole.

1. customThe ethanol was evaporated from the cooled reaction under vacuum
2. additionthe residue diluted with water
3. filtrationfiltered
4. extractionThe filtrate was extracted with ethyl acetate (x2)
5. dry with materialthe extracts dried (MgSO4)
6. customthe solvent removed under vacuum