Dichloromethane → 1-acetyl-3-(4-fluorophenyl)-1H-indazole-5-carbonyl chloride

HRID 1272759노트

반응식

HRID 1272759 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](O)=[O:14])=[CH:10][CH:11]=2)[C:6]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[N:5]1)(=[O:3])[CH3:2].[Cl:23]CCl.C(Cl)(=O)C(Cl)=O>CN(C=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([Cl:23])=[O:14])=[CH:10][CH:11]=2)[C:6]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[N:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 224798881h-Indazole-5-carboxylic acid,1-acetyl-3-(4-fluorophenyl)-

생성물 1

HCID 224802271-acetyl-3-(4-fluorophenyl)-1H-indazole-5-carbonyl chloride수율 84%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a flask containing 1-acetyl-3-(4-fluorophenyl)-1H-indazole-5-carboxylic acid (1.5 g, 5.9 mmol) was added dichloromethane (80 mL) and oxalyl chloride (1.02 mL, 11.7 mmol). The reaction was allowed to stir under a nitrogen atmosphere overnight. To the flask was added a catalytic amount of DMF. The reaction was allowed to stir for three hours. TLC indicated reaction was complete. The solvent was removed and a solid formed to yield the title compound (1.57 g, 84% yield).

후처리

  1. stirringto stir for three hours
  2. customreaction
  3. customThe solvent was removed
  4. customa solid formed

출처 및 근거

ORD 기록
ord-30b56aa5aa6f4fbeadc2fa4c0014a5a2
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208513B2

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