Hydrochloric Acid → HCID 22480189, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl-3-benzo[d]furan-2-yl-1-perhydro-2H-pyran -2-yl-1H-indazole-5-carboxylate (500 mg, 1.2 mmol) in a solution of tetrahydrofuran, methanol, and water (2:1:1) (4 mL) was added sodium hydroxide (200 mg, 5 mmol). The reaction was allowed to reflux overnight at 65° C. The solution was neutralized with 1 N HCl and extracted with ethyl acetate to yield the title compound (350 mg, 40% yield). ES-MS (m/z) 363 [M+1]+.

Provenance & Evidence