HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-2-methyl-2-(methylthio)propanoyl-L-cysteine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | L-(+)-Cysteine | HCID 5862 | — |
| Reactant | 2-Methyl-2-(methylthio)propanoyl chloride | HCID 13471992 | — |
| Solvent | Potassium Carbonate | HCID 11430 | — |
| Product | N-2-methyl-2-(methylthio)propanoyl-L-cysteine | HCID 53027 | 89.8% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255446 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-1ca328e86dbf4115a5c3fbcde3584ea3 |
| Source note | uspto-grants-1981_03 |