2-(2-Furyl)-2-oxo-N-(3-{1-perhydro-2H-pyran-2-yl-5 [1-(triphenylmethyl)(1,2,4-triazol-3-yl)] (1H-indazol-3-yl)} phenyl)acetamide → HCID 178522020, Verbindung

HRID 1272962Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1272962
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:55])[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]4[N:29]=[CH:28][N:27](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[N:26]=4)[CH:23]=3)[N:18](C3CCCCO3)[N:17]=2)[CH:11]=1)=[O:8]>Cl.O1CCOCC1>[NH:27]1[CH:28]=[N:29][C:25]([C:22]2[CH:23]=[C:24]3[C:19](=[CH:20][CH:21]=2)[NH:18][N:17]=[C:16]3[C:12]2[CH:11]=[C:10]([NH:9][C:7](=[O:8])[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)=[O:55])[CH:15]=[CH:14][CH:13]=2)=[N:26]1

Komponenten

4

Edukt 1

HCID 224802062-(2-Furyl)-2-oxo-N-(3-{1-perhydro-2H-pyran-2-yl-5 [1-(triphenylmethyl)(1,2,4-triazol-3-yl)] (1H-indazol-3-yl)} phenyl)acetamide

Produkt 1

HCID 178522020HCID 178522020, VerbindungAusbeute 5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-(2-Furyl)-2-oxo-N-(3-{1-perhydro-2H-pyran-2-yl-5[1-(triphenylmethyl)(1,2,4-triazol-3-yl)](1H-indazol-3-yl)}phenyl)acetamide was dissolved in 4 mL of 4.0 N HCl in 1,4-dioxane and the reaction was stirred at room temperature for 4 h. After neutralization with aqueous NaHCO3, the crude product was extracted in ethyl acetate and purified by preparative HPLC (0.0048 g, 5% yield over 2 steps): 1H NMR (CD3OD) δ 8.80 (s, 1H), 8.43 (d, 1H), 8.11 (br s, 1H), 8.10 (d, 1H), 8.01 (s, 1H), 7.94 (d, 1H), 7.87 (d, 1H), 7.72 (br d, 1H), 7.58 (t, 1H), 6.77 (dt, 1H); ES-MS (m/z) 399.

Aufarbeitung

  1. extractionAfter neutralization with aqueous NaHCO3, the crude product was extracted in ethyl acetate
  2. custompurified by preparative HPLC (0.0048 g, 5% yield over 2 steps)

Quellen und Nachweise

ORD-Eintrag
ord-5157b57b22dc429c874d5d9d5af00588
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07208513B2

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