Cyclohexaneacetic acid → 2-Cyclohexyl-N-(3-{1-perhydro-2H-pyran-2-yl-5-[1-(triphenylmethyl)(1,2,4-triazol-3-yl)](1H-indazol-3-yl)}phenyl)acetamide

HRID 1272967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1272967
[CH:1]1([CH2:7][C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.CN(C)CCCN=C=NCC.[O:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]1[N:29]1[C:37]2[C:32](=[CH:33][C:34]([C:38]3[N:42]=[CH:41][N:40]([C:43]([C:56]4[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=4)([C:50]4[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=4)[C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)[N:39]=3)=[CH:35][CH:36]=2)[C:31]([C:62]2[CH:63]=[C:64]([NH2:68])[CH:65]=[CH:66][CH:67]=2)=[N:30]1>ClCCl>[CH:1]1([CH2:7][C:8]([NH:68][C:64]2[CH:65]=[CH:66][CH:67]=[C:62]([C:31]3[C:32]4[C:37](=[CH:36][CH:35]=[C:34]([C:38]5[N:42]=[CH:41][N:40]([C:43]([C:44]6[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=6)([C:50]6[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=6)[C:56]6[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=6)[N:39]=5)[CH:33]=4)[N:29]([CH:24]4[CH2:25][CH2:26][CH2:27][CH2:28][O:23]4)[N:30]=3)[CH:63]=2)=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

5

Edukt 3

HCID 21363Cyclohexaneacetic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 211011823-(1-perhydro-2H-pyran-2-yl-5-[1-(triphenylmethyl)(1,2,4-triazol-3-yl)]-1H-indazol-3-yl}phenylamine

Produkt 1

HCID 224801082-Cyclohexyl-N-(3-{1-perhydro-2H-pyran-2-yl-5-[1-(triphenylmethyl)(1,2,4-triazol-3-yl)](1H-indazol-3-yl)}phenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 2-cyclohexylacetic acid (0.071 g, 0.498 mmol) in 2.0 mL of dichloromethane, was added 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (EDCI) as a solid (0.105 g, 0.548 mmol). The solution was stirred at room temperature for 10 min before 3-{1-perhydro-2H-pyran-2-yl-5-[1-(triphenylmethyl)(1,2,4-triazol-3-yl)]-1H-indazol-3-yl}phenylamine (0.150 g, 0.248 mmol), dissolved in 1 mL of dichloromethane was added. The reaction was stirred at room temperature overnight. The reaction mixture was then partitioned between dichloromethane and water. (Yield not calculated) ES-MS (m/z) 727 [M+H]+.

Aufarbeitung

  1. additionwas added
  2. customThe reaction mixture was then partitioned between dichloromethane and water
  3. custom(Yield not

Quellen und Nachweise

ORD-Eintrag
ord-47181bf6da3444d3b4c28270f575ae5e
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07208513B2

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