Hydrazine → HCID 12587996, compound

HRID 1272975Notes

Reaction equation

HRID 1272975 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][C:8]([O:10]C)=O.[NH2:12][NH2:13]>C(O)C>[NH2:12][NH:13][C:8](=[O:10])[CH2:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 5214606Methyl piperidin-2-ylacetate

Product 1

HCID 12587996HCID 12587996, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 2-piperidylacetate (1.082 mL, 5.84 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.283 mL, 5.84 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a gummy white solid in a quantitative yield and was used without further purification: ES-MS (m/z) 158 [M+H]+.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as a gummy white solid in a quantitative yield
  5. customwas used without further purification

Sources & evidence

ORD record
ord-e124249dffc94b568ce894a982876f22
Source dataset
uspto-grants-2007_04
Patent number
US07208513B2

Reaction notes

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