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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273099Generated: November 1, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273099

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
Reagent4-MethylmorpholineHCID 7972—
ReagentMethanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157—
SolventAcetonitrileHCID 6342—
ProductHCID 178487187HCID 1784871872.56%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-7380a05100de4c6f95a7d088796b905a
Source noteAniline amide coupling reaction