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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273124Generated: October 30, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273124

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
ReagentDiisopropylethylamineHCID 81531—
ReagentBis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 152842—
SolventAcetonitrileHCID 6342—
ProductHCID 178487187HCID 17848718734.12%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-ff0c195bb81e4bf18ea70cc3fbde923f
Source noteAniline amide coupling reaction