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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273143Generated: November 1, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273143

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
Reagent4-MethylmorpholineHCID 7972—
ReagentDiphenylphosphinic chlorideHCID 73910—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178487187HCID 17848718747.92%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-05e0b9caa18f411e8defa3f36cd7b3db
Source noteAniline amide coupling reaction