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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273144Generated: November 1, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273144

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
ReagentDiphenylphosphinic chlorideHCID 73910—
ReagentDiisopropylethylamineHCID 81531—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178487187HCID 17848718751.84%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-3520a35ed81d4bd4ba5ea4cb17942cdf
Source noteAniline amide coupling reaction