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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273145Generated: October 31, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273145

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
Reagent1-MethylimidazoleHCID 1390—
ReagentDiphenylphosphinic chlorideHCID 73910—
SolventAcetonitrileHCID 6342—
ProductHCID 178487187HCID 17848718746.34%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-d047e36e1c26484fbc254839acbb82a5
Source noteAniline amide coupling reaction