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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273146Generated: October 31, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273146

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
Reagent2,6-LutidineHCID 7937—
ReagentDiphenylphosphinic chlorideHCID 73910—
SolventAcetonitrileHCID 6342—
ProductHCID 178487187HCID 17848718727.33%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-2707a9372996465daf4fda078843b994
Source noteAniline amide coupling reaction