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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273155Generated: October 31, 2026

Indomethacin → HCID 178487187, compound

https://huagongshe.com/reaction/1273155

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant4-Amino-2-(trifluoromethyl)benzonitrileHCID 522170—
Reagent4-MethylmorpholineHCID 7972—
Reagent6-Cyano-N,N,2-trimethyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-iminium hexafluorophosphateHCID 57348955—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178487187HCID 1784871871.59%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-510b12c400ab4b7eb75e98565a5cef40
Source noteAniline amide coupling reaction