HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylthio-1-methylamino-2-nitroethylene → Desmethylranitidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylthio-1-methylamino-2-nitroethylene | HCID 123549 | — |
| Reactant | 5-[[(2-Aminoethyl)thio]methyl]-N-methyl-2-furanmethanamine | HCID 20209492 | — |
| Product | Desmethylranitidine | HCID 163116 | — |
Reaction Steps
A mixture of 2-[[[5-(methylamino)methyl-2-furanyl]methyl]thio]ethanamine (0.9 g) and N-methyl-1-methylthio-2-nitro-etheneamine was heated at 100°-120° for 30 mins under water pump pressure. The residue was purified by column chromatography (silica/methanol: 0.88 ammonia) to give N-[2-[[[5-(methylamino)methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine which was crystallised from acetonitrile m.p. 106°-108° (0.65 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255440 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-bcb94db76b4442c5b7791ef685e693ea |
| Source note | uspto-grants-1981_03 |