Indomethacin → HCID 178487182, compound

HRID 1273337Notes

Reaction equation

HRID 1273337 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.Nc1cc(-c2ccccc2)nn1-c1ccccc1>CC#N.Cn1ccnc1.O=P(Cl)(c1ccccc1)c1ccccc1>COc1ccc2c(c1)c(CC(=O)Nc1cc(-c3ccccc3)nn1-c1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1999691,3-Diphenyl-1H-pyrazol-5-amine

Product 1

HCID 178487182HCID 178487182, compoundYield 52.2%

Reagents, catalysts & solvents 3

HCID 13901-MethylimidazoleReagentHCID 73910Diphenylphosphinic chlorideReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-261be9f6ba0848a0812cfc8f05bdc68e
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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