1,3-Dimethoxybenzene → 2,4-Dimethoxybenzene-1-sulfonic acid

HRID 127337Notes

Reaction equation

HRID 127337 reaction equation
Cl[S:2]([OH:5])(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1>C(Cl)(Cl)Cl>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([O:14][CH3:15])[CH:11]=[CH:12][C:13]=1[S:2]([OH:5])(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 90251,3-DimethoxybenzeneHCID 24638Chlorosulfonic acid

Product 1

HCID 123740672,4-Dimethoxybenzene-1-sulfonic acid

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution prepared by adding 57 ml of chlorosulfonic acid to 250 ml of chloroform, was added dropwise 50 g of 1,3-dimethoxybenzene at a temperature below 5° C. with stirring. After stirring at 5° C. for 30 minutes, the crystals thus-precipitated were collected by filtration and washed with 100 ml of chloroform.

Workup

  1. customTo a solution prepared
  2. stirringAfter stirring at 5° C. for 30 minutes
  3. customthe crystals thus-precipitated
  4. filtrationwere collected by filtration
  5. washwashed with 100 ml of chloroform

Sources & evidence

ORD record
ord-3f2ac173084c4469ab33ebf5ddab9768
Source dataset
uspto-grants-1981_03
Patent number
US04255509

Reaction notes

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