Indomethacin → HCID 178487188, compound

HRID 1273517Notes

Reaction equation

HRID 1273517 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(Cl)c(N)c1>CC#N.CN(C)C(=[F+])N(C)C.Cn1ccnc1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1cc(C#N)ccc1Cl)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1044643-Amino-4-chlorobenzonitrile

Product 1

HCID 178487188HCID 178487188, compoundYield 14.45%

Reagents, catalysts & solvents 3

HCID 13901-MethylimidazoleReagentHCID 178483998HCID 178483998, compoundReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-520f086ac19440ae8fcee0626ccc4671
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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