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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1273533Generated: October 31, 2026

Indomethacin → HCID 178487188, compound

https://huagongshe.com/reaction/1273533

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndomethacinHCID 3715—
Reactant3-Amino-4-chlorobenzonitrileHCID 104464—
Reagent1-MethylimidazoleHCID 1390—
ReagentDiphenylphosphinic chlorideHCID 73910—
SolventDimethylformamideHCID 6228—
ProductHCID 178487188HCID 17848718811.61%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.26434/chemrxiv
Source datasetAniline amide coupling reaction
ORD IDord-acb53c8004694381a16813cffa2ee983
Source noteAniline amide coupling reaction