Indomethacin → HCID 178487188, compound

HRID 1273541Notes

Reaction equation

HRID 1273541 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(Cl)c(N)c1>CC#N.CCOC(=O)C(C#N)=N[O+]=C(N(C)C)N(C)C.Cn1ccnc1.F[P-](F)(F)(F)(F)F>COc1ccc2c(c1)c(CC(=O)Nc1cc(C#N)ccc1Cl)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 1044643-Amino-4-chlorobenzonitrile

Product 1

HCID 178487188HCID 178487188, compoundYield 9.37%

Reagents, catalysts & solvents 3

HCID 13901-MethylimidazoleReagentHCID 573489556-Cyano-N,N,2-trimethyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-iminium hexafluorophosphateReagentHCID 6342AcetonitrileSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-a4ed5321818241138ca6f7d4662fc17e
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

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