Ethanolamine → HCID 12784115, compound

HRID 127389Notes

Reaction equation

HRID 127389 reaction equation
C(O[C:4]([C:6]1[C:21](=[O:22])[N:20]([CH2:23][CH3:24])[C:9]2[N:10]=[C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:12]=[CH:13][C:8]=2[C:7]=1Cl)=[O:5])C.[NH2:26][CH2:27][CH2:28][OH:29]>>[CH2:23]([N:20]1[C:9]2[N:10]=[C:11]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:12]=[CH:13][C:8]=2[C:7]([NH:26][CH2:27][CH2:28][OH:29])=[C:6]([C:4]([NH:26][CH2:27][CH2:28][OH:29])=[O:5])[C:21]1=[O:22])[CH3:24]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 12784117HCID 12784117, compound

Product 1

HCID 12784115HCID 12784115, compound

Procedure

To 2 g. (0.0056 mole) of 5-chloro-7,8-dihydro-8-ethyl-7-oxo-2-phenylpyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (prepared by the method of the first paragraph of Example 3) was added 20 ml. of 2-aminoethanol and this mixture was heated at reflux for 1.5 hours. The reaction mixture was chilled in ice and the product collected on a filter and recrystallized from ethanol to give 1.7 g. of product.--m.p. 250°-253° C.

Workup

  1. additionwas added 20 ml
  2. temperatureat reflux for 1.5 hours
  3. temperatureThe reaction mixture was chilled in ice
  4. customthe product collected on
  5. filtrationa filter
  6. customrecrystallized from ethanol
  7. customto give 1.7 g

Sources & evidence

ORD record
ord-deb1f1ba3886476ea58609dd33a89059
Source dataset
uspto-grants-1981_03
Patent number
US04255568

Reaction notes

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