HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl-7-methylsulfamoyl-1,4-benzodioxane-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2,3-Dihydro-7-(N-methylsulphamoyl)-1,4-benzodioxin-5-carboxylic acid | HCID 6455317 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl-7-methylsulfamoyl-1,4-benzodioxane-5-carboxylate | HCID 54343297 | 85% |
Reaction Steps
750 ml of methanol were introduced into a balloon flask provided with a condenser. Then, under cooling, 273 g of concentrated sulfuric acid and 160 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carboxylic acid were added. The mixture was heated under reflux, cooled and poured into water and sodium carbonate. The precipitate was dried off, washed and dried. 143 g of methyl-7-methylsulfamoyl-1,4-benzodioxane-5-carboxylate were obtained (M.P.: 159°-160° C.: yield: 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255580 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-6064d75672864123861b447ab232f637 |
| Source note | uspto-grants-1981_03 |