Acetic Anhydride → 3-Fluorophthalic anhydride

HRID 1274059Notes

Reaction equation

HRID 1274059 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=O)[C:3]=1[C:11]([OH:13])=[O:12].C(OC(=O)C)(=O)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:5]([O:13][C:11](=[O:12])[C:3]=12)=[O:7]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 3453813-Fluorophthalic acid

Product 1

HCID 695513-Fluorophthalic anhydride

Procedure

15 g of 3-fluorophthalic acid are mixed with 16.6 g of acetic anhydride and refluxed for 3 hrs. After removal of unreacted acetic anhydride the remaining white solid is recrystalized from toluene.

Workup

  1. temperaturerefluxed for 3 hrs
  2. customAfter removal of unreacted acetic anhydride the remaining white solid
  3. customis recrystalized from toluene

Sources & evidence

ORD record
ord-0f3e7fcba18241beb0c737d8ddd1fe52
Source dataset
uspto-grants-2000_12
Patent number
US06156704

Reaction notes

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