HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyric anhydride → Isobutyrylproline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyric anhydride | HCID 7346 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | (2S)-1-propanoylpyrrolidine-2-carboxylic acid | HCID 676544 | — |
| Reactant | HCID 13895197 | HCID 13895197 | — |
| Product | Isobutyrylproline | HCID 15324300 | 96% |
Reaction Steps
[Isobutyryl9 ]Didemnin B (33) and [Isobutyryl9, D-Pro8 ] Didemnin B (34). L-Pro (1.15 g, 0.01 mol) was treated with isobutyric anhydride in a procedure like the N-propionylproline synthesis to give N-isobutyrylproline (1.8 g, 96%): fine crystals, mp 80-82° C.; [α]D25 -8.7° (c 1.56, CHCl3). 1H NMR Anal. (C9H15NO3) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06156724 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-ff17177206504628aeb091ea657000ee |
| Source note | uspto-grants-2000_12 |