Morpholine → HCID 53670703, compound

HRID 1274103Notes

Reaction equation

[CH3:1][C:2]1([CH3:28])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([O:14][C:15]3[CH:16]=[C:17]4[C:22](=[CH:23][CH:24]=3)[C:21]([C:25](Cl)=[O:26])=[CH:20][CH:19]=[CH:18]4)[CH:5]=[CH:4][C:3]1=2.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[CH3:1][C:2]1([CH3:28])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([O:14][C:15]3[CH:16]=[C:17]4[C:22](=[CH:23][CH:24]=3)[C:21]([C:25]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[O:26])=[CH:20][CH:19]=[CH:18]4)[CH:5]=[CH:4][C:3]1=2

Participants

Reactant 2

HCID 8083Morpholine

HCID 22120165HCID 22120165, compound

Product 1

HCID 53670703HCID 53670703, compoundYield 70.6%

Procedure

Utilizing a procedure analogous to that of Example 16(b), 593 mg (1.5 mmol) of 6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyloxy)naphthoyl chloride were reacted with 320 μl (3.6 mmol) of morpholine to provide 470 mg (70%) of the expected amide, having a melting point of 118°-20° C.

Sources & evidence

ORD record: ord-1dfeaa75a6004f9f913fbc81082ff539
Source dataset: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06156750

Reaction notes

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