Toluene → HCID 53634043, compound

Participants

Reaction Steps

A mixture of intermediate (1) (0.03 mol), ethyl (5-chloropentyl)carbamate (0.04 mol), potassium iodide (0.1 g) and Na2CO3 (5.7 g) in toluene (250 ml) was stirred and refluxed overnight. The reaction mixture was cooled, stirred in water (200 ml), and the layers were separated. The organic phase was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 95/5). The pure fractions were collected and the solvent was evaporated, yielding 7 g of ethyl [5-(3,4-dihydrobenzofuro[3,2-c]pyridin-2(1H)-yl)pentyl]carbamate (interm. 15).

Provenance & Evidence