HCID 9827071, compound → HCID 9932845, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (14) (0.062 g, 0.13 mmol) in trifluoroacetic acid (3 mL) was capped with a drying tube and stirred at 25° C. for 12 h. The reaction mixture was evaporated to a light brown oily residue (0.08 g, quantitative yield); 1H NMR (DMSO) δ 7.68 (d, 2H, J=8.7), 7.25 (s, 1H), 7.23 (s, 1H), 6.66 (d, 2H, J=8.7), 4.54 (d, 2H, J=12.0), 4.15 (s, 3H), 3.91 (s, 3H), 3.85 (s, 3H), 3.73 (m, 1H), 3.45 (t, 2H, J=12.0), 2.10 (m, 2H), 1.53 (m, 2H): 13C NMR (DMSO) δ 167.5, 156.5, 151.4, 149.7, 148.9, 147.1, 131.2, 117.0, 111.2, 106.1, 103.0, 102.8, 101.1, 56.2, 55.9, 55.3, 47.9, 43.7, 30.9; HRMS (FAB) m/z 439.2001 (M+H)+ (C23H26N4O5 requires 439.1981); Anal. (C23H26N4O5 ·1CF3COOH·1/2H2O) C, H, N.

Provenance & Evidence