HCID 10787310, compound → HCID 10665271, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (8) (0.067 g, 0.17 mmol) in HCl (10 mL, 4M in 1,4-dioxane) was capped with a drying tube and stirred at 25° C. for 12 h. The reaction mixture was concentrated to give a white solid residue (0.065 g, 99%); 1H NMR (DMSO) δ 8.31 (s, 1H), 8.06 (m, 5H), 7.70 (d, 2H, J=8.7), 7.60 (m, 2H), 6.70 (d, 2H, J=8.8), 3.76 (m, 5H), 2.17 (m, 4H); 13C NMR (DMSO) δ 167.4, 151.2, 132.7, 131.2, 129.9, 128.0, 127.8, 127.4, 119.3, 117.4, 111.4, 66.3, 29.0; HRMS (FAB) m/z 347.1770 (M+H)+ (C22H22N2O2 requires 347.1760); Anal. (C22H22N2O2 ·2HCl) C, H, N.

Provenance & Evidence