反应详情

温度

0 °C

To a solution of 3,3-dimethyl-4-(3-methoxyphenyl)butanoic acid (6.7 g, 0.03 mol) in DCM (100 mL) at 0° C. was added a solution of bromine (1.55 mL, 0.03 mol) in DCM (13 mL) dropwise. After addition the solution was stirred at 0° C. for 1 h then the solution was washed with water (3×100 mL), dried (Na2SO4) and evaporated. The product (8.45 g, 94%) was isolated as a brown oil and used without further purification. 1H NMR (360 MHz, CDCl3) δ 1.12 (6H, s), 2.36 (2H, s), 2.98 (2H, s), 3.80 (3H, s), 6.65 (1H, dd, J=8.7 and 3.1 Hz), 6.85 (1H, d, J=3.1 Hz), 7.43 (1H, d, J=8.7 Hz).

1. additionAfter addition the solution
2. washthe solution was washed with water (3×100 mL)
3. dry with materialdried (Na2SO4)
4. customevaporated