1,4-Dioxane hydrochloride → HCID 86754545, compound

HRID 1274170Notes

Reaction equation

HRID 1274170 reaction equation
[ClH:1].O1CCOCC1.[N:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:34])[C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH:23]C(OC(C)(C)C)=O)=[CH:18][C:17]=2[O:31][CH2:32][CH3:33])=[CH:10][CH:9]=1>>[ClH:1].[ClH:1].[N:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:34])[C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH2:23])=[CH:18][C:17]=2[O:31][CH2:32][CH3:33])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21846511HCID 21846511, compound

Product 1

HCID 86754545HCID 86754545, compound

Procedure

4N Hydrochloric acid-dioxane (1 ml) was added to N-(4- pyridyl)-4-tert-butoxycarbonylaminomethyl-2-ethoxybenzamide (60 mg), and the mixture was stirred at room temperature for 1 hour. After the reaction, the solvent was evaporated under reduced pressure. The obtained crystals were recrystallized from methanol-ethyl acetate to give 40 mg of N-(4- pyridyl)-4-aminomethyl-2-ethoxybenzamide dihydrochloride 1/2 hydrate having a melting point of 251° C. (dec.).

Workup

  1. customAfter the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. customThe obtained crystals were recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-f6414f6f00484356be50b6eb2e440ac4
Source dataset
uspto-grants-2000_12
Patent number
US06156766

Reaction notes

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