HCID 22120841, compound → HCID 22120755, compound

HRID 1274227Notes

Reaction equation

HRID 1274227 reaction equation
C([O:3][C:4](=[O:35])[CH:5]([C:23]1[O:24][C:25]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:26][CH:27]=1)[NH:6][C:7](=[O:22])[CH:8]([CH2:17][S:18]C(=O)C)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C>C(Cl)(Cl)Cl>[CH2:28]([C:25]1[O:24][C:23]([CH:5]([C:4]([OH:35])=[O:3])[NH:6][C:7](=[O:22])[CH:8]([CH2:17][SH:18])[CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:27][CH:26]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 1

HCID 22120841HCID 22120841, compound

Product 1

HCID 22120755HCID 22120755, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from 2-[(5-benzyl)furan-2-yl]-N-[2-(acetylthiomethyl)-4-phenylbutyryl]glycine ethyl ester (Description 43) by the procedure described in Example 24. vmax (CHCl3) 3430, 3294, 1727, 1662 cm-1. δ (CD3SOCD3) 1.70-1.80 (2H, m), 2.40-2.74 (5H, m), 3.90 and 3.94 (2H, two s's), 5.30-5.35 (1H, m), 5.99-6.02 (1H, m), 6.22 and 6.26 (1H, two d's, J 4.10 Hz), 7.09-7.32 (10H, m), 8.48 (1H, d, J 6.98 Hz), m/z 423 (M+). [Found (HRMS): 423.1503. Calc for C24H25NO4S; 423.1504].

Sources & evidence

ORD record
ord-d47f2e92958a416fa1be390b7fd120ad
Source dataset
uspto-grants-2000_12
Patent number
US06156774

Reaction notes

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