Methanol → HCID 9867537, compound

HRID 1274228Notes

Reaction equation

HRID 1274228 reaction equation
C([O:3][C:4](=[O:34])[CH:5]([C:23]1[S:24][C:25]([CH2:28][CH:29]2[CH2:33][CH2:32][O:31][CH2:30]2)=[CH:26][CH:27]=1)[NH:6][C:7](=[O:22])[CH:8]([CH2:17][S:18]C(=O)C)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C.CO.C(Cl)(Cl)Cl>ClCCl>[O:31]1[CH2:32][CH2:33][CH:29]([CH2:28][C:25]2[S:24][C:23]([CH:5]([C:4]([OH:34])=[O:3])[NH:6][C:7](=[O:22])[CH:8]([CH2:17][SH:18])[CH2:9][CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:27][CH:26]=2)[CH2:30]1

Participants

5

Reactant 3

HCID 887MethanolHCID 6212ChloroformHCID 22120834HCID 22120834, compound

Product 1

HCID 9867537HCID 9867537, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from 2-[5-(tetrahydrofuran-3-ylmethyl)thien-2-yl]-N-[2-(acetylthiomethyl)-4-phenylbutyryl]glycine ethyl ester (Description 47) by the procedure described in Example 24 except that the eluent used was 10% methanol in dichloromethane. vmax (CHCl3) 3409, 3293, 1648 and 1603 cm-1. δ (CD3SOCD3) 1.44-1.61 (1H, m), 1.70-1.82 (1H, m), 1.85-2.03 (1H, m), 2.30-2.80 (8H, m), 3.29-3.40 (2H, m), 3.53-3.76 (3H, m), 5.13 and 5.25 (1H, two d's, J 6.55 Hz), 5.70 and 5.77 (1H, two s's), 6.64 (1H, d, J 3.23 Hz), 6.74-6.84 (1H, m), 7.11-7.31 (5H, m), 7.87 and 8.12 (1H, two d's, J 6.68 Hz).

Sources & evidence

ORD record
ord-4fb50cde5d7248e2be5ec29f26adacf6
Source dataset
uspto-grants-2000_12
Patent number
US06156774

Reaction notes

Loading…