Methanol → HCID 22120846, compound

HRID 1274229Notes

Reaction equation

HRID 1274229 reaction equation
C([O:3][C:4](=[O:34])[CH:5]([C:23]1[S:24][C:25]([CH2:28][N:29]2[N:33]=[N:32][CH:31]=[N:30]2)=[CH:26][CH:27]=1)[NH:6][C:7](=[O:22])[CH:8]([CH2:17][S:18]C(=O)C)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C.CO.C(Cl)(Cl)Cl>ClCCl>[N:30]1[N:29]([CH2:28][C:25]2[S:24][C:23]([CH:5]([C:4]([OH:34])=[O:3])[NH:6][C:7](=[O:22])[CH:8]([CH2:17][SH:18])[CH2:9][CH2:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)=[CH:27][CH:26]=2)[N:33]=[N:32][CH:31]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 6212ChloroformHCID 22120845HCID 22120845, compound

Product 1

HCID 22120846HCID 22120846, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from 2-[5-(2-tetrazolylmethyl)thien-2-yl]-N-[2-(acetylthiomethyl)-4-phenylbutyryl]glycine ethyl ester (Description 54) using the procedure described in Example 24 except that the eluent used was 10% methanol in dichloromethane. vmax (CHCl3) 3294 and 1646 cm-1. δ (CD3SOCD3) 1.68-1.81 (2H, m), 2.42-2.73 (5H, m), 5.74-5.83 (1H, m), 6.09 (2H, s), 6.88-6.96 (1H, m), 7.05-7.31 (6H, m), 8.20-8.31 (1H, m), 8.94 and 8.98 (1H, two s's). m/z 530 (M-H)-.

Sources & evidence

ORD record
ord-ca67c89394bb4154b81f94a9a46a2cf9
Source dataset
uspto-grants-2000_12
Patent number
US06156774

Reaction notes

Loading…