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Methanol → Methyl-8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 8-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid | HCID 20544690 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl-8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylate | HCID 20544706 | 96.5% |
反応手順
396 g of methanol were introduced into a balloon flask provided with a condenser and then 51 g of sulfuric acid and 114.5 g of 8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid were added while cooling. The mixture was heated under reflux and then poured into 485 cm3 of water and 40 g of sodium carbonate. The precipitate was dried off, washed and dried. 110.5 g of methyl-8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylate were obtained (M.P.: 202°-203° C.; yield: 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04255580 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-0b2a4c5bac6349d2943df43a0e0fa484 |
| 出典メモ | uspto-grants-1981_03 |