HCID 10155033, compound → HCID 9968553, compound

HRID 1274288Notes

Reaction equation

HRID 1274288 reaction equation
[C:1]1([C:7]2[N:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:14][CH:13]=3)[N:10]=[C:9]([CH:22]([F:24])[F:23])[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>C(O)C.[Pd]>[CH:1]1([C:7]2[N:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH2:21])(=[O:19])=[O:20])=[CH:14][CH:13]=3)[N:10]=[C:9]([CH:22]([F:23])[F:24])[CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 10155033HCID 10155033, compound

Product 1

HCID 9968553HCID 9968553, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-[5-(1-Cyclohexenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (Example 142) (0.31 g, 0.88 mmol) was dissolved in ethanol (15 mL), 10% palladium on charcoal was added, and the suspension was stirred at room temperature under hydrogen (36 psi) for 18.25 hours. The reaction was filtered through celite, and the ethanol removed in vacuo to give a white solid, which was recrystallized from methylene chloride/isooctane (0.31 g, 99%): mp 199-203° C.; 1H NMR (acetone-d6) 300 MHz 8.05 (d, J=8.7 Hz, 2H), 7.60 (d, J=8.5 Hz, 2H), 6.69 (t, J=55.0 Hz 1 H), 6.47 (s, 1H), 5.02 (br s, 2H), 2.67 (m, 1H), 171-1.88(m, 5H), 1.24-1.43 (m, 5H); 19F NMR (acetone-d6) 300 MHz: -112.86 (d).

Workup

  1. filtrationThe reaction was filtered through celite
  2. customthe ethanol removed in vacuo
  3. customto give a white solid, which
  4. customwas recrystallized from methylene chloride/isooctane (0.31 g, 99%)

Sources & evidence

ORD record
ord-89272cb94334439e97ceeb19d9bf7e4d
Source dataset
uspto-grants-2000_12
Patent number
US06156781

Reaction notes

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