Water → HCID 22120904, compound

HRID 1274349Notes

Reaction equation

HRID 1274349 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21]1[S:22][CH:23]=[CH:24][CH:25]=1.[Br:26]N1C(=O)CCC1=O.CCOCC.O>C(#N)C>[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:16])([F:15])[F:17])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[C:21]1[S:22][C:23]([Br:26])=[CH:24][CH:25]=1

Participants

6

Reactant 4

HCID 962WaterHCID 3283Diethyl EtherHCID 67184N-bromobutanimideHCID 9930987HCID 9930987, compound

Product 1

HCID 22120904HCID 22120904, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(thien-2-yl)pyrazole (0.153 g) in acetonitrile (12 ml) was added N-bromosuccinimide (0.068 g). The mixture was left at room temperature for 1.5 hours and then poured into ether (50 ml) and water (50 ml). The layers were separated and the aqueous phase extracted with a second portion of ether (50 ml). The combined organic layers were washed with water (25 ml), then dried (MgSO4) and evaporated. The residue was purified by column chromatography on silica gel (10 g) eluted with dichloromethane. Combination and evaporation of suitable fractions gave the title compound as an off-white solid, m.p. 214° C.

Workup

  1. customThe layers were separated
  2. extractionthe aqueous phase extracted with a second portion of ether (50 ml)
  3. washThe combined organic layers were washed with water (25 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customThe residue was purified by column chromatography on silica gel (10 g)
  7. washeluted with dichloromethane
  8. customCombination and evaporation of suitable fractions

Sources & evidence

ORD record
ord-4b97968c97ce454d8b65b59ea16d9b06
Source dataset
uspto-grants-2000_12
Patent number
US06156782

Reaction notes

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