Thionyl Chloride → HCID 22120979, compound

Participants

Reaction Steps

To a solution of 4-[4-(benzyloxy)-phenoxy]-3-nitrobenzyl alcohol (9.43 g, 26.9 mmol) in chloroform (60 ml) was added thionyl chloride (2 ml), followed by stirring at room temperature for 6 hours. After allowing to stand overnight, the reaction solution was washed with water and dried, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography [eluent; hexane - chloroform (1:1)] to give 4-[4-(benzyloxy)-phenoxy]-3-nitrobenzyl chloride (7.63 g).

Provenance & Evidence