Trifluoroacetic acid → HCID 178424870, compound

Participants

Reaction Steps

To a solution of (2-{2-(3,5-dimethylphenyl)-5-[1-methyl-1-(4-methyl-1H-imidazol-2-yl)ethyl]-1H-indol-3-yl}ethyl)carbamic acid tert-butyl ester (353 mg in 8 mL methylene chloride) at 0° C. was added 0.56 mL anisole followed by 2.5 mL trifluoroacetic acid and the mixture stirred at room temperature. After 2 hours, the mixture was concentrated in vacuo and the residual acid removed by azeotrope with toluene. The residue was solvated in methylene chloride and washed sequentially with 0.5N sodium hydroxide and brine. Purification of the concentrate by preparative tlc on silica gel (methylene chloride:methanol:ammonium hydroxide, 80:20:0.25) to give the title compound (198 mg).

Provenance & Evidence