HCID 9906481, compound → HCID 9885682, compound

Participants

Reaction Steps

100 mg of 4-(5-methyl-2,4-dioxo-5-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)-benzonitrile, as prepared in Example 1, were dissolved in 20 ml of a 7/3 ethanol/water mixture and stirred for 5 days at room temperature. The reaction mixture was evaporated to dryness and then purified by chromatography on an RP18 silica column (eluent: 6/4 water/acetonitrile). 18 mg of (4-cyano-3-(trifluoromethyl)phenyl)(3,3,3-trifluoro-2-hydroxy-2-methylpropionyl)carbamic acid were obtained, for a yield of 17%.

Provenance & Evidence