Propylamine → 1-(3,4-Dichlorophenyl)-3-propyl-1-(3,3,3-trifluoro-2-hydroxy-2-methylpropionyl)urea

Participants

Reaction Steps

200 mg of 3-(3,4-dichlorophenyl)-5-methyl-5-(trifluoromethyl)oxazolidine-2,4-dione were dissolved in 10 ml of dichloromethane. 55 μl of propylamine were added. The reaction mixture was stirred for 24 hours at room temperature. After evaporation, the residue was purified by chromatography on a silica column (eluent: dichloromethane). 155 mg of 1-(3,4-dichlorophenyl)-3-propyl-1-(3,3,3-trifluoro-2-hydroxy-2-methylpropionyl)urea were obtained, for a yield of 63%.

Provenance & Evidence