HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Propanediol → HCID 23249714, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | 3-((Tert-butyldimethylsilyl)oxy)propanal | HCID 3662392 | — |
| Reactant | 3-[(Tert-butyldimethylsilyl)oxy]propan-1-ol | HCID 4077791 | — |
| Reactant | HCID 13524712 | HCID 13524712 | — |
| Product | HCID 23249714 | HCID 23249714 | — |
Reaction Steps
3-[(tert-Butyldimethylsilyl)oxy]propanal 42 is produced using propane-1,3-diol 40 as a starting material by monosilylation into 3-[(tert-butyldimethylsilyl)oxy]-1-propanol 41 being done first according to a method of P. G. McDougal, J. G. Rico, Y. Oh, B. D. Condon, J. Org. Chem. 1986, 51, 3388-3390, which then is oxidized to aldehyde 42 with DMSO/oxalyl chloride (A. Jenmalm, W. Berts, Y. Li, K. Luthmann, I. Csoregh, U. Hacksell, J. Org. Chem. 1994, 59, 1139-1148).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06156905 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-b515d3e2cfc34b9c980f661ed32e9ce0 |
| Source note | uspto-grants-2000_12 |