1,3-Propanediol → 3-((Tert-butyldimethylsilyl)oxy)propanal

HRID 1274489Notes

Reaction equation

HRID 1274489 reaction equation
C(O)CCO.[Si:6]([O:13][CH2:14][CH2:15][CH2:16][OH:17])([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]>>[Si:6]([O:13][CH2:14][CH2:15][CH:16]=[O:17])([C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 104421,3-PropanediolHCID 40777913-[(Tert-butyldimethylsilyl)oxy]propan-1-ol

Product 1

HCID 36623923-((Tert-butyldimethylsilyl)oxy)propanal

Procedure

Synthesis by monosilylation of 1,3-propanediol and subsequent Swern oxidation of the 3-[(t-butyldimethylsilyl)oxy]-1-propanol that is produced.

Workup

  1. customis produced

Sources & evidence

ORD record
ord-d203b298f9574657b4f9a15b102c6827
Source dataset
uspto-grants-2000_12
Patent number
US06156905

Reaction notes

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