反应详情

A solution of 3-[3-(6-methoxy-m-tolyl)-1,2-benzisothiazol-5-yl]-1-methyl-6-(trifluoromethyl)-2,4(1H,3H)-pyrimidinedione (111 g, 0.248 mol) in methylene chloride is cooled to -5° C., treated over one hour with a 1 M solution of boron tribromide in methylene chloride (322 mL, 0.322 mol), stirred for one hour, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title product as a yellow solid (105 g, 98.1%) which is identified by NMR spectral analyses.

1. washwashed sequentially with water and brine
2. dry with materialdried over anhydrous magnesium sulfate
3. concentrationconcentrated in vacuo