HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7beta-Phenoxyacetamido-3-methoxy-3-cephem-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | Diphenylmethyl (6R-trans)-3-methoxy-8-oxo-7-(phenoxyacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate | HCID 6453042 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7beta-Phenoxyacetamido-3-methoxy-3-cephem-4-carboxylic acid | HCID 12784142 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
0.87 ml of anisole is added to a solution of 2.0 g (3.78 mmols) of 7β-phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid diphenylmethyl ester in 5 ml of methylene chloride and the mixture is cooled to 0° C. and left to stand for 1 hour after adding 1.2 ml of trifluoroacetic acid. The reaction mixture is concentrated in vacuo and the residue is crystallised from acetone/ether. 7β-Phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid of melting point 170° C. (decomposition) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255328 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-bb586f0ad34d4bcd9284fede280667f9 |
| Source note | uspto-grants-1981_03 |