Sodium Hydroxide → HCID 70100056, compound

HRID 1274600Notes

Reaction equation

HRID 1274600 reaction equation
[CH3:1][N:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5](=[O:12])[N:4]([C:13]2[CH:14]=[CH:15][C:16]3[S:20][N:19]=[C:18]([C:21]4[CH:26]=[C:25]([O:27][CH:28]([CH3:32])[C:29]([OH:31])=[O:30])[CH:24]=[CH:23][C:22]=4[CH3:33])[C:17]=3[CH:34]=2)[C:3]1=[O:35].[OH-].[Na+:37]>O>[CH3:1][N:2]1[C:7]([C:8]([F:10])([F:11])[F:9])=[CH:6][C:5](=[O:12])[N:4]([C:13]2[CH:14]=[CH:15][C:16]3[S:20][N:19]=[C:18]([C:21]4[CH:26]=[C:25]([O:27][CH:28]([CH3:32])[C:29]([O-:31])=[O:30])[CH:24]=[CH:23][C:22]=4[CH3:33])[C:17]=3[CH:34]=2)[C:3]1=[O:35].[Na+:37]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70096977HCID 70096977, compound

Product 1

HCID 70100056HCID 70100056, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-{{2-{5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-1,2-benzisothiazol-3-yl}-p-tolyl}oxy}propionic acid (0.500 g) and sodium hydroxide (0.0360 g) in water is stirred at room temperature overnight, concentrated in vacuo to one-half volume, and filtered to give the title product as a solid which is identified by NMR spectral analysis.

Workup

  1. concentrationconcentrated in vacuo to one-half volume
  2. filtrationfiltered

Sources & evidence

ORD record
ord-e4aa0bb2febf49dca9d12b135999ae9f
Source dataset
uspto-grants-2000_12
Patent number
US06156700

Reaction notes

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