反应详情

A mixture of [(5-amino-1,2-benzisothiazol-3-yl)oxy]acetonitrile (4.30 g, 21.0 mmol) and 2-dimethylamino-4-(trifluoromethyl)-6H-1,3-oxazin-6-one (4.37 g, 21.0 mmol) in acetic acid is refluxed for three hours, stirred overnight at room temperature, and poured into an ice-water mixture. The resultant aqueous mixture is filtered to obtain a solid. The solid is washed with water and dried overnight in a vacuum oven at 55° C. to give the title product as a brown solid (2.63 g, mp 254-258° C.).

1. temperatureis refluxed for three hours
2. filtrationThe resultant aqueous mixture is filtered
3. customto obtain a solid
4. washThe solid is washed with water
5. customdried overnight in a vacuum oven at 55° C.