Hydrochloric Acid → HCID 54329570, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl{{{5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-1,2-benzisothiazol-3-yl}methyl}sulfonyl}acetate (1.00 g, 0.00210 mol), acetic acid and 10% hydrochloric acid (2.00 ml) is stirred overnight at 60° C. Additional hydrochloric acid (37%, 1.20 ml) is added and the mixture is stirred 5 hours at 80° C. The mixture is cooled to room temperature, poured into ice water with stirring, and filtered to give the title compound as a white solid (0.760 g, 78.4%, mp 215° C.) which is identified by NMR spectral analysis.

Provenance & Evidence