Ammonia → HCID 20287106, compound

Participants

Reaction Steps

Following essentially the same procedure but substituting methyl 2-hydroxy-5-[1-hydroxy-2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]benzoate hydrochloride and methyl 2-hydroxy-5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]benzoate hydrochloride for the methyl 2-hydroxy-5-[1-hydroxy-2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]benzoate hydrochloride above and using gaseous methylamine in lieu of ammonia results in the preparation of 2-hydroxy-5-[1-hydroxy-2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methylbenzamide monohydrochloride hydrate, having a m.pt. of 188°-9° C. (dec.), and 2-hydroxy-5-[1-hydroxy-2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-methylbenzamide monohydrochloride monohydrate, having a m.pt. of 162°-5° C. (dec.), respectively.

Provenance & Evidence